Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
نویسندگان
چکیده
منابع مشابه
Distinct Recycling of Active and Inactive β1 Integrins
Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell adhesion. Integrin activity toward the components of the extracellular matrix is regulated by the ability of these receptors to switch between active and inactive conformations. Several cellular signalling pathways hav...
متن کاملIntegrins outside focal adhesions transmit tensions during stable cell adhesion
Integrins coupled with other proteins form protein complexes named focal adhesions (FA) which are considered as the primary sites for cellular forces transduction during cell stable adhesion. Cell traction forces transmitted by FAs and integrin tensions inside FAs have been extensively studied. However, it remains unknown whether integrins outside FAs can transmit tension, and if so, what is th...
متن کاملActin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.
Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and link them to the actin filament (F-actin) cytoskeleton to mediate cell adhesion and migration. Cytoskeletal forces in migrating cells generated by polymerization- or contractility-driven "retrograde flow" of F-actin from the cell leading edge have been hypothesized to mediate integrin activation for liga...
متن کاملFocal adhesions
What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2018
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201707075